Under President Olusegun’s administration Sani was appointed as a member of the African Union African Peer Review Mechanism, Member of the United Nation Reform Committee, appointed by Nigerian President as a Member of the Presidential Committee on Prison Reforms, Presidential Committee on the Control of Violent Crimes and Illegal Weapons, Presidential Committee on Petroleum Products Prices, Presidential Committee on Conflict Resolution, Member of the Niger State Judicial Commission of Inquiry, Member of the National Political Reform Conference, Member of the Charles Taylor Investigation Committee, also appointed by the Nigerian Government as a Board Member of the Nigerian Extractive Industry Transparency Initiative (NEITI). Sani was a Member of the Presidential Committee on National Security and Civic Responsibility.
- In 2003, Sani contested for the Senate under Alliance for Democracy (AD) and lost to Senator Muktar Aruwa of the All Nigerian Peoples Party (ANPP).
- In 2011, he contested for the senate under Congress for Progressive Change (CPC) and lost to Senator Sani Saleh in the primaries.
- In 2015, Sani won the senate seat after defeating Senator Sani Saleh in the primaries and defeated Senator Muktar Aruwa in the General Election.
- On 4 September 2015, he became the first and only Nigerian Senator to declare his assets publicly.
He is currently the Senate Committee Chairman on Local & Foreign Debts and also serves as the Vice Chairman on Senate Committee on Foreign Affairs.